SMFM Podcast: The impact of the HYPITAT I Trial on Obstetric Management and Outcomes for Gestational Hypertension and Preeclampsia

Speaker: Dr. Catherine De Sonnaville
Date recorded: January 2019

Dr. De Sonnaville describes the HYPITAT 1 trial, highlighting the results showing the beneficial effects of induction of labor in pregnancies complicated by hypertensive disorders in term pregnancies. The recommendation of inducing patients with hypertensive disorders of pregnancy at term has been adopted by national guidelines. The study involved adult patients, singleton pregnancies in the cephalic presentation, at 36-41 weeks gestation. They had two cohorts – 1. Pregnancies complicated by hypertensive disorders – gestational hypertension or Preeclampsia and 2. Pregnancies not complicated by hypertensive disorders. The outcomes were onset of labor, maternal complications and neonatal complications. They compared the proportions of the period before the trial (2000-2005) to the period after the trial (2008-2014). They performed a subgroup analysis, compared the HYPITAT recruiting hospitals to the non-recruiting hospitals for the patients with hypertensive disorders.